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New Reliance Intake Form!

The new form helps Reliance staff decide whether UNC can and will agree to serve as the IRB of record for external sites. This video will show you where to find the intake form in IRBIS, how to complete it correctly, and submit it to OHRE. Published 7/5/2024.

A reliance agreement may be required when you are collaborating with researchers external to UNC who are engaged in non-exempt human subjects research.

Due to recent changes in the request process, the Reliance Team is revising the guidance on reliance agreement requests. New guidance will be published soon.

Questions regarding reliance agreements, please email IRBreliance@unc.edu.


Reliance Documents for Collaborations with Organizations or Institutions

These are samples of the forms the IRB uses to document reliance arrangements. The UNC Reliance Team will be responsible for preparing these forms when specific reliance requests are made. They are provided here for informational purposes, and should not be completed by the study team unless during consultation with the Reliance Team.


Reliance Documents for Collaborating Individuals

These forms are fillable pdf’s and may be used by the research team.


Requesting Reliance on a Commercial IRB

UNC allows investigators to utilize a commercial IRB for industry-sponsored, multi-center, clinical research studies for which one of the following approved commercial IRBs have been appointed as the commercial IRB by the Sponsor or CRO and the commercial IRB has already approved the study.

  • WIRB-Copernicus
  • Advarra (created by merger of Chesapeake IRB and Schulman IRB in 2017; Advarra acquired Quorum IRB in 2019)
  • Sterling

This Commercial IRB Cover Page will be completed by the IRB staff and uploaded to the initial submission in IRBIS. The commercial IRB will not review UNCs involvement without this cover page.

The Commercial IRB Checklist can be used by study teams to assist in drafting and submitting a request to rely on a commercial IRB.