AdvanTx Support
Projects or ideas that are deemed to have significant potential will receive the following benefits:
- Mentorship: Scientific support will be provided to develop a therapeutic target concept or project.
- Translation: Support will be provided to access and coordinate resources and funding through UNC and external organizations.
- Commercial Assessment: When applicable, engage with key potential stakeholders on campus and externally to obtain feedback and assess market potential.

Therapeutic Protein or Gene
AdvanTx Support
Therapeutic Mentorship
- Develoment of therapeutic hypothesis
- Human translational data
- Technical feasibility
- Preclinical tools & reagents
- Safety assessment
- Clinical development strategy & patient selection
- Competitive Analysis
- Project de-risking
- Therapeutic Workplan Development
Translation
- UNC School of Pharmacy: Eshelman Institute for Innovation
- UNC Lineberger Cancer Center
- UNC School of Medicine Pilot Awards
- NC TraCS
- UNC OTC Grants
- UNC Idea Grants
- NIH/NSF
- NC Biotech Center
- Pinnacle Hill
- Foundations
Drug Discovery Research Plan & Budget to IND
![]() Lead Identification 1 year, $2 – $4M |
![]() Lead Optimization 1-2 years, $3 – $5M |
![]() <1 year, $1.5 – 2.5M |
![]() 1 year, $1.5 – $2.5M |
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Medchem
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Biophysical & Biochemical assay screening
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In vitro ADME
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Cellular assay screening
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In vivo DMPK
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Selectivity screening
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Broad selectivity
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In vivo screening
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PK/PD
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Clinical TE assay
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IP filing
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GLP Tox
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Developability/Formulation
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GLP Safety Pharm
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Non-GLP Scale Up, API Prep & CMC
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GLP Genetox
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Acute & Chronix Tox
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GLP hERG
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Additional DMPK
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IND Prep
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Target validated & Hit ID
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Chemical matter ID
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Precandidate ID
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Development Candidate ID
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IND Ready
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