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Gene Symbol Propeller Fold AA Length Disease Association(s)
1 AHCTF1 Mixed 2266 Pan-cancer
2 AMBRA1 WD40 1298 Pan-cancer
3 ATG16L1 WD40 607 IBD, Diabetes
4 ATRN KELCH 1429 Kidney Cancer
5 BBS1 PQQ 593 Bardet-Biedl Syndrome
6 BRWD3 WD40 1802 MENTAL RETARDATION, X-LINKED 93 (disorder)
7 CDC20 WD40 499 Brain Cancers
8 CIAO1 WD40 339 Pan-cancer
9 CLTC Clathrin 1675 Pan-cancer
10 COP1 WD40 731 Immuno-oncology
11 COPA WD40 1224 AUTOIMMUNE INTERSTITIAL LUNG, JOINT, AND KIDNEY DISEASE
12 CORO1A WD40 461 IMMUNODEFICIENCY 8
13 CPSF1 WD40 1443 Pan-cancer
14 DMXL1 WD40 3027 Pan-cancer
15 DPP6 PeptidaseS9 865 MENTAL RETARDATION, AUTOSOMAL DOMINANT 33
16 DYNC2I1 WD40 1066 Jeune thoracic dystrophy
17 DYNC2I2 WD40 536 Jeune thoracic dystrophy
18 EED WD40 441 COHEN-GIBSON SYNDROME
19 EMC1 PQQ 993 CEREBELLAR ATROPHY, VISUAL IMPAIRMENT, AND PSYCHOMOTOR RETARDATION
20 EML1 Mixed 815 BAND HETEROTOPIA
21 FBXW11 WD40 542 Colorectal, Gastic Cancers
22 FBXW7 WD40 707 Ovarian
23 FZR1 WD40 496 Ovarian Cancer
24 GEMIN5 Mixed 1508 Pan-cancer
25 GLDN Olfactomedin 551 LETHAL CONGENITAL CONTRACTURE SYNDROME 11
26 GNB1 WD40 340 GNB1 Encephalopathy
27 GNB3 WD40 340 Childhood Obesity; Hypertension; type 2 diabetes
28 GNB4 WD40 340 CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE F
29 GNB5 WD40 395 LANGUAGE DELAY AND ATTENTION DEFICIT-HYPERACTIVITY DISORDER/COGNITIVE IMPAIRMENT WITH OR WITHOUT CARDIAC
30 GRWD1 WD40 446 Ovarian
31 HERC1 Mixed 4861 MACROCEPHALY, DYSMORPHIC FACIES, AND PSYCHOMOTOR RETARDATION
32 IFT80 WD40 777 Jeune thoracic dystrophy
33 ITGAV Mixed 1048 Breast, Colorectal, and Lung Cancers
34 KATNB1 WD40 655 Pancreatic Cancer
35 KBTBD2 KELCH 623 Ewing Sarcoma, Bone Cancer
36 KEAP1 KELCH 624 Non-small cell lung cancer
37 KIF21A WD40 1674 Fibrosis Of Extraocular Muscles, Congenital, 1
38 KLHL24 KELCH 600 Epimermolysis Bullosa
39 KNTC1 WD40 2209 Colorectal, Gastic Cancers
40 LRP2 Mixed 4655 Donnai-Barrow syndrome
41 LRP8 Mixed 963 Blood Cancers
42 LZTR1 KELCH 840 Noonan Syndrome 2
43 MAPKBP1 WD40 1514 NEPHRONOPHTHISIS 20
44 MED16 Mixed 877 Haematopoietic And Lymphoid Cancers
45 MEGF8 KELCH 2845 CARPENTER SYNDROME 2
46 MET Mixed 1390 Central Nervous System Cancers
47 MMP2 Hemopexin 660 TORG-WINCHESTER SYNDROME
48 MMP20 Hemopexin 483 Amelogenesis Imperfecta, Hypomaturation Type, Iia2
49 MMP25 Hemopexin 562 Inflammation
50 NBAS WD40 2371 Developmental delay (disorder)
51 NEU1 Sialidases 415 Type I Mucolipidosis, Inflammation
52 NLE1 WD40 485 Pan-cancer
53 NOL11 WD40 719 Pan-cancer
54 NUP133 WD40 1156 NEPHROTIC SYNDROME, TYPE 18
55 PAFAH1B1 WD40 410 Miller-Dieker syndrome
56 PAK1IP1 WD40 392 Gastric Cancer
57 PALB2 WD40 1186 Reproductive Cancers; Cancers with reversions in BRCA2
58 PDCL Phosducin 301 Skin and Kidney Cancers
59 PHIP WD40 1821 DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES
60 PLXNC1 Mixed 1568 Inflammation
61 PRG4 Hemopexin 1404 CAMPTODACTYLY-ARTHROPATHYCOXA VARA-PERICARDITIS SYNDROME
62 PRPF4 WD40 522 RETINITIS PIGMENTOSA 70
63 RACK1 WD40 317 Osteoperosis; Bone Loss
64 RAE1 WD40 368 Pan-cancer
65 RAG2 KELCH 527 Severe Combined Immunodeficiency
66 RBBP4 WD40 425 Colorectal, Gastic Cancers
67 RBBP7 WD40 425 Pan-cancer; Neurodegeneration
68 RFWD3 WD40 774 Ovarian Cancer
69 RPGR RCC1 1020 Retinitis Pigmentosa
70 RPTOR WD40 1335 Pan-cancer
71 RRP9 WD40 475 Gastric Cancer
72 SCAP WD40 1279 Hypertriglyceridemia; Hyperlipidemia; Pan-cancer
73 SEC31A WD40 1220 Lung Cancers (SEC31A-ALK fusions)
74 SEC31A WD40 1220 Lymphomas
75 SEH1L WD40 360 Gastric Cancer
76 TAF1C WD40 869 Pan-cancer
77 TAF5 WD40 800 Skin Cancer
78 THOC6 WD40 341 Breast and Esophogael Cancers
79 TRIM2 NHL 744 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R
80 UBR4 WD40 5183 Pan-cancer
81 UTP18 WD40 556 Pan-cancer
82 VPS39 Clathrin 886 Blood Cancers
83 WDHD1 WD40 1129 Pan-cancer
84 WDR1 WD40 606 Blood Cancer, Head and Neck Cancers
85 WDR11 WD40 1224 HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA
86 WDR18 WD40 432 Lung Cancers
87 WDR24 WD40 790 Ovarian Cancer
88 WDR25 WD40 544 Pan-cancer
89 WDR26 WD40 661 Ovarian Cancer
90 WDR36 WD40 951 Breast and Pancreatic Cancers
91 WDR45 WD40 360 Beta-propeller protein-associated neurodegeneratio
92 WDR48 WD40 677 Ovarian and Uterine Cancers
93 WDR7 Mixed 1490 Head and Neck Cancer
94 WDR72 WD40 1102 Amelogenesis Imperfecta, Hypomaturation Type, Iia3
95 WDR73 WD40 378 Ovarian Cancer
96 WDR77 WD40 342 MTAP-deleted cancers
97 WDR82 WD40 313 Pan-cancer
98 WDR83 WD40 315 Pan-cancer
99 WRAP73 WD40 460 Haematopoietic And Lymphoid Cancers
100 WSB2 WD40 404 Skin, Liver, Thyroid Cancers