2021 List of Interesting Propellor Targets

	Gene Symbol	Propeller Fold	AA Length	Disease Association(s)
1	AHCTF1	Mixed	2266	Pan-cancer
2	AMBRA1	WD40	1298	Pan-cancer
3	ATG16L1	WD40	607	IBD, Diabetes
4	ATRN	KELCH	1429	Kidney Cancer
5	BBS1	PQQ	593	Bardet-Biedl Syndrome
6	BRWD3	WD40	1802	MENTAL RETARDATION, X-LINKED 93 (disorder)
7	CDC20	WD40	499	Brain Cancers
8	CIAO1	WD40	339	Pan-cancer
9	CLTC	Clathrin	1675	Pan-cancer
10	COP1	WD40	731	Immuno-oncology
11	COPA	WD40	1224	AUTOIMMUNE INTERSTITIAL LUNG, JOINT, AND KIDNEY DISEASE
12	CORO1A	WD40	461	IMMUNODEFICIENCY 8
13	CPSF1	WD40	1443	Pan-cancer
14	DMXL1	WD40	3027	Pan-cancer
15	DPP6	PeptidaseS9	865	MENTAL RETARDATION, AUTOSOMAL DOMINANT 33
16	DYNC2I1	WD40	1066	Jeune thoracic dystrophy
17	DYNC2I2	WD40	536	Jeune thoracic dystrophy
18	EED	WD40	441	COHEN-GIBSON SYNDROME
19	EMC1	PQQ	993	CEREBELLAR ATROPHY, VISUAL IMPAIRMENT, AND PSYCHOMOTOR RETARDATION
20	EML1	Mixed	815	BAND HETEROTOPIA
21	FBXW11	WD40	542	Colorectal, Gastic Cancers
22	FBXW7	WD40	707	Ovarian
23	FZR1	WD40	496	Ovarian Cancer
24	GEMIN5	Mixed	1508	Pan-cancer
25	GLDN	Olfactomedin	551	LETHAL CONGENITAL CONTRACTURE SYNDROME 11
26	GNB1	WD40	340	GNB1 Encephalopathy
27	GNB3	WD40	340	Childhood Obesity; Hypertension; type 2 diabetes
28	GNB4	WD40	340	CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE F
29	GNB5	WD40	395	LANGUAGE DELAY AND ATTENTION DEFICIT-HYPERACTIVITY DISORDER/COGNITIVE IMPAIRMENT WITH OR WITHOUT CARDIAC
30	GRWD1	WD40	446	Ovarian
31	HERC1	Mixed	4861	MACROCEPHALY, DYSMORPHIC FACIES, AND PSYCHOMOTOR RETARDATION
32	IFT80	WD40	777	Jeune thoracic dystrophy
33	ITGAV	Mixed	1048	Breast, Colorectal, and Lung Cancers
34	KATNB1	WD40	655	Pancreatic Cancer
35	KBTBD2	KELCH	623	Ewing Sarcoma, Bone Cancer
36	KEAP1	KELCH	624	Non-small cell lung cancer
37	KIF21A	WD40	1674	Fibrosis Of Extraocular Muscles, Congenital, 1
38	KLHL24	KELCH	600	Epimermolysis Bullosa
39	KNTC1	WD40	2209	Colorectal, Gastic Cancers
40	LRP2	Mixed	4655	Donnai-Barrow syndrome
41	LRP8	Mixed	963	Blood Cancers
42	LZTR1	KELCH	840	Noonan Syndrome 2
43	MAPKBP1	WD40	1514	NEPHRONOPHTHISIS 20
44	MED16	Mixed	877	Haematopoietic And Lymphoid Cancers
45	MEGF8	KELCH	2845	CARPENTER SYNDROME 2
46	MET	Mixed	1390	Central Nervous System Cancers
47	MMP2	Hemopexin	660	TORG-WINCHESTER SYNDROME
48	MMP20	Hemopexin	483	Amelogenesis Imperfecta, Hypomaturation Type, Iia2
49	MMP25	Hemopexin	562	Inflammation
50	NBAS	WD40	2371	Developmental delay (disorder)
51	NEU1	Sialidases	415	Type I Mucolipidosis, Inflammation
52	NLE1	WD40	485	Pan-cancer
53	NOL11	WD40	719	Pan-cancer
54	NUP133	WD40	1156	NEPHROTIC SYNDROME, TYPE 18
55	PAFAH1B1	WD40	410	Miller-Dieker syndrome
56	PAK1IP1	WD40	392	Gastric Cancer
57	PALB2	WD40	1186	Reproductive Cancers; Cancers with reversions in BRCA2
58	PDCL	Phosducin	301	Skin and Kidney Cancers
59	PHIP	WD40	1821	DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES
60	PLXNC1	Mixed	1568	Inflammation
61	PRG4	Hemopexin	1404	CAMPTODACTYLY-ARTHROPATHYCOXA VARA-PERICARDITIS SYNDROME
62	PRPF4	WD40	522	RETINITIS PIGMENTOSA 70
63	RACK1	WD40	317	Osteoperosis; Bone Loss
64	RAE1	WD40	368	Pan-cancer
65	RAG2	KELCH	527	Severe Combined Immunodeficiency
66	RBBP4	WD40	425	Colorectal, Gastic Cancers
67	RBBP7	WD40	425	Pan-cancer; Neurodegeneration
68	RFWD3	WD40	774	Ovarian Cancer
69	RPGR	RCC1	1020	Retinitis Pigmentosa
70	RPTOR	WD40	1335	Pan-cancer
71	RRP9	WD40	475	Gastric Cancer
72	SCAP	WD40	1279	Hypertriglyceridemia; Hyperlipidemia; Pan-cancer
73	SEC31A	WD40	1220	Lung Cancers (SEC31A-ALK fusions)
74	SEC31A	WD40	1220	Lymphomas
75	SEH1L	WD40	360	Gastric Cancer
76	TAF1C	WD40	869	Pan-cancer
77	TAF5	WD40	800	Skin Cancer
78	THOC6	WD40	341	Breast and Esophogael Cancers
79	TRIM2	NHL	744	CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R
80	UBR4	WD40	5183	Pan-cancer
81	UTP18	WD40	556	Pan-cancer
82	VPS39	Clathrin	886	Blood Cancers
83	WDHD1	WD40	1129	Pan-cancer
84	WDR1	WD40	606	Blood Cancer, Head and Neck Cancers
85	WDR11	WD40	1224	HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA
86	WDR18	WD40	432	Lung Cancers
87	WDR24	WD40	790	Ovarian Cancer
88	WDR25	WD40	544	Pan-cancer
89	WDR26	WD40	661	Ovarian Cancer
90	WDR36	WD40	951	Breast and Pancreatic Cancers
91	WDR45	WD40	360	Beta-propeller protein-associated neurodegeneratio
92	WDR48	WD40	677	Ovarian and Uterine Cancers
93	WDR7	Mixed	1490	Head and Neck Cancer
94	WDR72	WD40	1102	Amelogenesis Imperfecta, Hypomaturation Type, Iia3
95	WDR73	WD40	378	Ovarian Cancer
96	WDR77	WD40	342	MTAP-deleted cancers
97	WDR82	WD40	313	Pan-cancer
98	WDR83	WD40	315	Pan-cancer
99	WRAP73	WD40	460	Haematopoietic And Lymphoid Cancers
100	WSB2	WD40	404	Skin, Liver, Thyroid Cancers