Central/External Reliance Agreements

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REQUESTING RELIANCE ON A CENTRAL IRB (REVISED 2/25/2015)

Requesting reliance on a Central IRB

UNC allows investigators to utilize a Central IRB for industry-sponsored, multi-center, clinical research studies for which one of the following approved Central IRBs have been appointed as the Central IRB by the Sponsor or CRO and the Central IRB has already approved (or is in the process of approving) the study.

How to Request a Reliance Agreement (Revised 8/12/2016)

Guidance DocumentRequesting Reliance on an External IRB or Extending UNC IRB Oversight to an External Group or Individual

A reliance agreement is required when you are collaborating with researchers external to UNC who are engaged in research. This document describes how to complete the IRBIS application to request one of the following:

  •  UNC provide IRB oversight for institutions, groups or organizations external to UNC
  •  UNC provide IRB oversight for individuals (whose collaboration is NOT on behalf of an external institution, group or organization) external to UNC
  •  UNC rely on an Institutional IRB
  •  UNC rely on an Independent/Central IRB
  •  UNC rely on the NCI CIRB

UNC’s IRB Authorization Agreement (IAA) template