Phone: (919) 966-5569
Fax: (919) 966-8429
CB 7193
Chapel Hill, NC 27599-7193
iacuc@med.unc.edu

Amendment Categories

Approved March 26, 2004

Review by the individual(s) indicated in parentheses.

Personnel Changes, other than investigator (IACUC Training and Compliance Unit)
Title Changes/Funding Changes (IACUC Administration)
Change in number of animals, if less than or equal to 5% of the approved number and not in Pain Category E. Some exceptions to 5% limit may be made for the addition of transgenic lines. (Chair or Vice Chair)
Additional drugs under item H of protocol if procedures are the same and drugs are not used to induce toxicity (Chair or Vice Chair)
Change of strain of animals within a species (Chair or Vice Chair)
- e.g. different knockouts or Sprague Dawley to Wistar
Increase in duration of experiment if not a post-surgical protocol (Veterinarian)
- e.g. follow animals for effects of drug from 2 weeks to 4 weeks
- e.g. monitor spontaneous tumor development from 4 months to 8 months
Method of bleeding, if IACUC approved method (Training and Compliance Coordinator)
Minor changes in behavioral/ observation procedures (Chair or Vice Chair)
- e.g. increasing observation period for locomotor activity from 5 to 10 minutes

(The above were selected because they are likely common changes that are usually benign without pain or suffering.)

All significant amendments are handled by designated review and assigned to the Chair or Vice Chair unless otherwise noted in parentheses.

Investigator transfers, only between faculty members in good standing
Method of euthanasia not including physical euthanasia (Veterinarian)
Change of anesthetic agent if switch is to an approved regimen for the species (Veterinarian)
Change in number of animals greater than 5% but less than or equal to 25% of the approved number
Move to Pain Category E (Veterinarian)
Changes in the degree of invasiveness of a procedure or discomfort to an animal
Use or withholding of analgesics (Veterinarian)
Changes in duration, frequency, or number of procedures performed on an animal

Change in animal species
Changes in animal number greater than 25%
Changes in objectives of a study
Addition of survival surgery (when no survival surgery described in original application)