Announcements

  • July 11, 2017: The Project Personnel section of the IRBIS application has been revised to clearly distinguish UNC staff from UNC Network Entity or Affiliate staff, and to separate staff from external institutions and independent investigators into distinct sections.  Click here to learn more…
  • June 14, 2017: The AAHRPP Accreditation Visit has been scheduled for Thursday, October 12th and Friday, October 13th.  Click here to learn more…
  • May 17, 2017: The Office of Human Research Ethics (OHRE) is pleased to announce the hiring of John Roberts, CIP as IRB Reliance Compliance Manager.  Click here to learn more…
  • May 4, 2017: The Office of Human Research Ethics (OHRE) Standard Operating Procedures (SOPs) were recently revised.  The revised SOPs will be effective on June 2, 2017.  Significant changes are outlined in the accompanying change log. Click here to learn more…
  • For older items, see News section

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Introduction to Human Research Subject Protection at UNC

Last year, over one million people took part in research studies at UNC-Chapel Hill. Who are these participants, who is studying them and why? Read more…

Organizational Structure

The Office of Human Research Ethics (OHRE) is responsible for ethical and regulatory oversight of research at the University of North Carolina at Chapel Hill that involves human subjects. OHRE supports and oversees the work of the Institutional Review Boards (IRBs). The IRBs at the University of North Carolina at Chapel Hill are organized by area of expertise.  The IRBs are:

Biomedical IRB (Committees A through D): Reviews research involving School of Medicine, School of Pharmacy, UNC Hospitals, and research in other units that involves biomedical interventions. Expertise is focused on medical, surgical, physiological or pharmacological studies. Includes research with drugs, devices, counseling, or other interventions. Studies that require dental or oncology expertise are reviewed by Biomedical Committee B or D.

Non-Biomedical IRB (Committee E):  A combination of the former Behavioral and Public Health-Nursing IRBs. Reviews research in psychology, child development, education, anthropology, information and library science, social work, journalism, and many other disciplines under Academic Affairs, as well as studies from the School of Public Health, School of Nursing, nursing-related studies at UNC Hospitals, non-medical research from the Injury Prevention Research Center, Carolina Population Center, Health Promotion Disease Prevention, and Sheps Center. Expertise is focused on research in behavioral and social sciences, the humanities, epidemiology and other research in a public health or nursing context.

IRB Safety Committee: This committee handles submissions that are atypical or otherwise outside the norm, as well as Unanticipated Problems Involving Risks to Subjects or Others (UPIRSO) and other compliance issues, Humanitarian Use Devices (HUDs), emergency research on single patients under a single subject treatment IND.  It meets monthly but can be convened rapidly should circumstances require.